PIRL Services

The level of support and service provided is tailored to each individual project.

We can provide support at all stages of the research process, including:

Advice on experimental design and choice of animal models
Development of surgical techniques
Generation and processing of imaging data (e.g., PET-CT, MRI, fluoroscopy, X-ray, etc.)
Preparation of applications to Animal Ethics Committees
Approval from regulatory bodies including the Office of Gene Technology Regulatory (OGTR) and Department of Agriculture, Fisheries and Forestry (DAFF)
Teaching, training, and workshops

PIRL offers a range of services for biotechnology and pharmaceutical companies wishing to establish safety or efficacy of their investigational new drugs and devices, in preparation for regulatory submission. We can conduct toxicity studies in rodent and non-rodent species per guidelines issued by regulatory agencies and international standards. Our research can be conducted to OECD Principles of Good Laboratory Practice (GLP).

Services

Safety and efficacy of medical devices, including implants, prosthetics, and surgical instruments in a range of small and large animal models.
Early Toxicology Screening - Dose Range Finding (DRFs) / Maximum tolerated dose (MTD)
Pharmacokinetic Studies
Acute Toxicity Studies - Single-dose Studies
Repeat Dose Toxicity Studies
Sub-Acute Toxicity - Repeat dose 7/14/28 Day Studies
Sub Chronic Toxicity - Repeat Dose 90 Day Studies
Chronic Toxicity - Repeat dose 120/180 Day Studies

Depending on the substance and regulatory requirements, additional studies may be conducted to assess specific endpoints such as neurotoxicity and carcinogenicity.