Brain Organoid Therapeutics (BOT)
Innovating the future of human tissue-based drug screens in neurology and oncology
Brain Organoid Therapeutics (BOT) is a screening platform that leverages innovative human neural models in vitro to evaluate the efficacy and neurotoxicity of agents and therapeutics interacting with the nervous system.
Our expert team employs rigorous, state-of-the-art research methods to develop electrophysiologically-relevant neural models that closely mimic the human nervous system. Focused on scientific excellence and patient well-being, we collaborate with industry and academic researchers to provide our services and accelerate the translation of therapeutic breakthroughs while minimising neurotoxicity risks..
BOT is a collaboration between SAHMRI and Flinders University.
Visit the BOT website for more information
Specialised services
Preclinical modeling & screening
- Drug screening
- Induced pluripotent stem cells (iPSCs)
- 2D and 3D models in vitro
- Disease models
Computational analysis
- Machine learning and bioinformatics analysis
Functional characterisation & imaging
- Electrophysiology
- Neuronal phenotyping
- High content imaging
Clinical development
- Clinical trial support
Equipment
Automation & liquid handling
- Janus automated liquid handler
- Assist plus pipetting robot
- 3D Bioprinters
Advanced imaging & metabolic profiling
- High content confocal microscopes
- incucute live cell imaging system
- Seahorse real time cell metabolism analyzer
Electrophysiology Suite
- Whole-cell patch clamping
- Multi-electrode arrays
- Calcium imaging
Computational infrastructure
- Dedicated server (>400TB)
- High performance computing systems (HPCs)
Get in touch
SAHMRI is located on Kaurna Country. We pay respects to the Kaurna people of the Adelaide Plains and to all Aboriginal and Torres Strait Islander people. We are committed to embracing knowledge and culture as we continue our working journey to incorporate Aboriginal health research across all of our themes and further reconciliation.
Read more"Tirki nguta tappa tangka marninithi"
(Learning and knowledge are the pathway to alter the mind)
- Uncle Lewis Yerloburka O’Brien, Kaurna Elder
