Laboratory For Human Neurophysiology And Genetics

The laboratory bioengineers live human brain tissue in petri dishes, establishing a platform in vitro to facilitate the discovery and validation of treatments for brain disorders. The group's research is at the frontier of human cellular neuroscience research and translational applications that benefit global public health.

The goal of the Laboratory for Human Neurophysiology and Genetics is to increase the translational success of pre-clinical models.

The Bardy Laboratory is located in the flagship South Australian Health and Medical Research Institute (SAHMRI) in Adelaide and affiliated with the College of Medicine and Public Health at Flinders University.

The large majority of the work undertaken in the Laboratory for Human Neurophysiology and Genetics is based on human neuronal cultures derived from induced pluripotent stem cells (iPSC). New cell-reprogramming technologies provide the team with a unique advantage to study human neuronal physiology in health and disease.

The laboratory investigates the neurobiological and genetic predispositions of Parkinson's with iPSC-derived neuronal models as well as the biological properties of patient-derived glioblastoma cells and their interaction with neuronal microenvironment.

The team’s multidisciplinary analytical approach combines many technical expertise, including tissue culture, patch-clamping, live imaging, genomics, single-cell trancriptomics, flow cytometry, molecular biology, machine learning analysis and bioinformatics.