The TREAT study

Time-Restricted EATing to reduce the risk of developing type 2 diabetes (TREAT)
The TREAT study
Project Status: In progress
Project administered by: The University of Adelaide

Intensive nutrition and physical activity programs delay the progression to overt type 2 diabetes mellitus (T2DM) by up to 58% over 10 years. However, long-term adherence to lifestyle interventions that actively restrict energy intake continues to be poor.

Recent research shows that erratic and poor timing of meals is a contributing factor to chronic disease risk, including T2DM. This means that when we eat could be as - or more - important as what we eat for metabolic health.

Our work suggests that time restricted eating (TRE), whereby individuals are simply instructed to confine all energy intake to 8-10 hours per day, is a practical intervention that reduces glycated haemoglobin (HbA1c) and the glucose and insulin responses to meals in people with obesity and/or T2DM, at least in the short-term.

Importantly, TRE improved insulin sensitivity, blood pressure and oxidative stress, even without weight loss. This multi-centre randomised clinical trial will be the first world-wide to determine the longer-term effects of TRE on glucose control and cardio-metabolic health at three and 12 months follow up. We hypothesise TRE will be at least as effective as current practice guidelines in dietetics to improve glycaemic control in individuals at high risk of developing T2DM.

The impacts of TRE on body mass and body composition, markers of cardiovascular disease, wellbeing, quality of life and enablers and barriers to adherence will additionally be examined.

This project is funded by the Medical Research Future Fund